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Impatience leads to premature protocol abandonment or unnecessary dose increases
Navarro-Gonzalez JF, Sanchez-Nino MD, Donate-Correa J, et al
Oral glutathione supplements have historically shown poor bioavailability, and unlicensed intravenous glutathione infusions carry risks including infection and allergic reactions
To further elucidate the therapeutic mechanisms underlying D-CuPs multivalent interactions, comprehensive proteomic analysis revealed two pivotal transcriptional regulators, the tumor suppressor protein p53 and histone deacetylase 7 (HDAC7) to be potential mechanistic targets
Therefore, targeting ISCA2 is a potential strategy to induce ferroptosis in ccRCC[79]
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